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  • Title: Prophylaxis of Plasmodium falciparum infection in a human challenge model with WR 238605, a new 8-aminoquinoline antimalarial.
    Author: Brueckner RP, Coster T, Wesche DL, Shmuklarsky M, Schuster BG.
    Journal: Antimicrob Agents Chemother; 1998 May; 42(5):1293-4. PubMed ID: 9593172.
    Abstract:
    The prophylactic efficacy of WR 238605, a primaquine analog, was studied with a human Plasmodium falciparum challenge model. A single oral dose of 600 mg, administered 1 day prior to challenge, successfully protected three of four subjects. The fourth subject developed mild, oligosymptomatic malaria on day 31, with drug concentrations one-half of those in the protected individuals. WR 238605 appears to be a promising prophylactic drug for P. falciparum malaria.
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