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  • Title: Expression of antimetastatic gene nm23-H1 in epithelial ovarian cancer.
    Author: Qian M, Feng Y, Xu L, Zheng S, Zhou X.
    Journal: Chin Med J (Engl); 1997 Feb; 110(2):142-4. PubMed ID: 9594287.
    Abstract:
    OBJECTIVE: To investigate the expression of nm23-H1 in epithelial ovarian cancer. METHODS: A total of 55 specimens from patients with epithelial ovarian cancers, 15 patients with serous cancers, 7 with mucinous cancers, 17 with endometrioid cancers and 16 with adenocarcinomas, were examined for the expression of nm23-H1 by means of the immunohistochemical technique. RESULTS: The total positive rate was 23.64% (13/55). The tissular nm23-H1 immunostaining had significantly higher expression in mucinous cancer (57.14%) than in other histologic types of epithelial ovarian cancer (P < 0.05). Compared to that in the primary tumor, nm23-H1 expression in the omental metastatic tumor in the same patient was reduced. CONCLUSIONS: The expression rate of nm23-H1 is higher in the primary tumors than in the metastatic tumors and is different in various histologic subtypes of epithelial ovarian cancer. The expression of nm23-H1 may participate in the inhibitory process of tumor invasion.
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