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  • Title: Effects of thrombolytic therapy on recanalization in different starting time of treatment after acute myocardial infarction.
    Author: Shen L, Yang J, Hu Q, Teng Y, Han X, Yan S, Lian M, Xie M, Gu F.
    Journal: Chin Med J (Engl); 1997 Jan; 110(1):53-5. PubMed ID: 9594323.
    Abstract:
    OBJECTIVE: To investigate the effects of thrombolytic therapy on recanalization in different starting time of treatment after acute myocardial infarction. METHODS: 172 cases with intravenous thrombolytic agents were divided into 4 groups: < or = 2 hours, > 2-4 hours, > 4-6 hours and > 6-12 hours, according to the different starting time of therapy after onset of symptoms. RESULTS: The recanalization rates were 78.6%, 74%, 39. 6% and 14.3% in < or = 2 hours, > 2-4 hours, > 4-6 hours and > 6-12 hours, respectively. The recanalization rate within 4 hours was significantly higher than those in the groups of > 4-6 hours AND > 6-12 hours. The time interval from the initiation of thrombolytic therapy to reperfusion was increased as the starting time of thrombolysis after onset of symptoms was delayed. CONCLUSIONS: Starting time of thrombolysis within 4 hours after onset of acute myocardial infarction is of the best effect on recanalization.
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