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  • Title: Barbital alteration of central nervous system sensitivity to hexobarbital in the rat.
    Author: Schnell RC, Stoll RE, Prosser TD.
    Journal: Psychopharmacology (Berl); 1976 May 05; 47(1):93-6. PubMed ID: 959468.
    Abstract:
    Alteration in central nervous system (CNS) sensitivity to the hypnotic effect of the hexobarbital was assessed by analytical, electroencephalographic, and pharmacokinetic techniques in barbital-treated rats. Each of these conceptually diverse experimental methodologies yielded similar conclusions concerning the alteration of CNS sensitivity by barbital treatment.
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