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  • Title: Pathophysiology in endothelin-1 transgenic mice.
    Author: Theuring F, Thöne-Reinecke C, Vogler H, Schmager F, Rohmeiss P, Slowinski T, Neumayer HH, Hocher B.
    Journal: J Cardiovasc Pharmacol; 1998; 31 Suppl 1():S489-91. PubMed ID: 9595521.
    Abstract:
    Transgenic mice expressing the human endothelin-1 (ET-1) were generated. These mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. Consequently, a progressive decrease in renal blood flow and/or glomerular filtration rate was observed, demonstrated by altered creatinine clearance and by magnetic resonance imaging. These genetically altered transgenic mice provide an interesting animal model in which to elucidate the role of ET-1 in the modulation of renal hemodynamics and glomerular and tubule functions.
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