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  • Title: Effects of cannabinoids on the perfused rat heart.
    Author: Smiley KA, Karler R, Turkanis SA.
    Journal: Res Commun Chem Pathol Pharmacol; 1976 Aug; 14(4):659-75. PubMed ID: 959665.
    Abstract:
    In the isolated perfused rat heart cardiac rate and contractility are directly affected by four naturally occurring cannabis constituents, delta9-tetrahydrocannabinol, delta8-tetrahydrocannabinol, cannabinol and cannabidiol. All the drugs depressed myocardial contractility. Their effect on rate, however, was not uniform: delta8-Tetrahydrocannabinol produced cardiac arrhythmias but no other consistent change; both delta9-tetrahydrocannabinol and cannabinol caused tachycardia; but cannabidiol produced bradycardia, arrhythmias and asystole. In addition, as a consequent of the dispostion of the cannabinoids to accumulate in the isolated heart, high tissue concentrations appeared in conjunction with the direct cardiac effects.
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