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  • Title: [Relationship between INH-resistance and katG mutation in M. tuberculosis].
    Author: Zhang Z, Ma Y, Cheng S.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 1996 Dec; 19(6):346-9. PubMed ID: 9596816.
    Abstract:
    OBJECTIVE: To investigate the molecular mechanism of INH-resistance and the relationship between INH-resistance and KatG mutations. METHODS: Use the primers designed from the 5' end of the KatG gene to amplify 282bp fragments from INH-susceptible and -resistant M. tuberculosis isolates. Single strand conformation polymorphism (SSCP) for their PCR products were analysed. RESULTS: No katG gene sequence deletion was observed, mutations were detected in 17 of 30 INH-resistant strains and no gene perturbations were shown in 16 INH-susceptible isolates. CONCLUSION: The results suggested that mutation in katG gene was one of the most important INH-resistant mechanisms in M. tuberculosis.
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