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  • Title: [The effects of hyperinsulinmia and insulin-like growth factor-1 on hyperandrogenism in polycystic ovarian syndrome].
    Author: Liang X, Zhuang G, Fan Q.
    Journal: Zhonghua Yi Xue Za Zhi; 1997 Apr; 77(4):266-9. PubMed ID: 9596926.
    Abstract:
    OBJECTIVE: To investigate the effects of insulin (INS) and insulin-like growth factor-1 (IGF-1) on ovarian androgen production in women with polycystic ovarian syndrome (PCOS). METHOD: 48 patients with PCOS were divided into two groups based on body mass index (BMI) (24 were obese BMI > 25 and 24 nonobese) (BMI < 25). 10 women with normal weight and menstruation were recruited as controls. The serum LH, FSH and testosterone (T) levels were determined. 40 cases were measured INS, IGF-1, androstenodine (A) and sex hormone binding globulin (SHBG) after a 3-hour oral glucose tolerance test (OGTT). Ovarian stroma obtained from 10 patients with PCOS and 5 healthy women were cultured in the medium with high INS concentration (30 ng/ml and 60 ng/ml). The IGF-1 and A levels were determined. RESULTS: Two groups of patients with PCOS demonstrated significant hyperinsulinmia (HI) and hyperandrogenism. Significantly higher IGF-1 level was observed in nonobese patients (P < 0.01). Insulin markedly stimulated release of IGF-1 (4 times, P < 0.01) and A (6 times, P < 0.05) in incubation of ovarian stroma obtained from PCOS patients. A positive correlation between IGF-1 and A was present in the culture medium (r = 0.679, P < 0.05). The serum levels of SHBG were significantly lower in PCOS patients. CONCLUSION: The findings suggest that the women with PCOS have HI, since INS may play an important role in hyperandrogenism by upregulating IGF-1 system in ovary.
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