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  • Title: Thiomycalolides: new cytotoxic trisoxazole-containing macrolides isolated from a marine sponge Mycale sp.
    Author: Matsunaga S, Nogata Y, Fusetani N.
    Journal: J Nat Prod; 1998 May; 61(5):663-6. PubMed ID: 9599273.
    Abstract:
    Two new cytotoxic trisoxazole macrolides, thiomycalolides A (2) and B (3), have been isolated from a marine sponge Mycale sp. The structures were determined to be glutathione adducts of mycalolides A and B by interpretation of spectral data and chemical transformation. Thiomycalolides A and B are highly cytotoxic against P388 murine leukemia cells.
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