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  • Title: Adaptation in cyclic AMP signalling processes: a central role for cyclic AMP phosphodiesterases.
    Author: Houslay MD.
    Journal: Semin Cell Dev Biol; 1998 Apr; 9(2):161-7. PubMed ID: 9599411.
    Abstract:
    Cyclic AMP has provided the paradigm for the second messenger concept. Recent evidence has identified a complex array of isoforms of the enzymes involved in generation, destroying and transmitting the effects of this second messenger. These proteins provide a sophisticated system for organising cAMP signal transduction in specific intracellular compartments; for allowing integration with other signalling systems and for controlling the kinetics and hence reaction characteristics of cAMP signal transduction.
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