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  • Title: [Comparison of the reactivation effects of the HI-6 oxime and obidoximeon cyclosin-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats].
    Author: Kassa J.
    Journal: Ceska Slov Farm; 1998 Feb; 47(1):47-50. PubMed ID: 9600150.
    Abstract:
    In experiments on male rats the reactivating effects of oxime HI-6 and obidoxime in combination with atropine on acetylcholinesterase, inhibited by the highly toxic organophoshate cyclosin, were compared in various parts of the brain (frontal cortex, pontomedullar region, hypothalamus, hippocampus, basal ganglia) and the diaphragm. After intramuscular administration of cyclosine in a sublethal dose, a medium-serious inhibition of the diaphragmatic acetylcholinesterase and a various inhibition of this enzyme in the brain with the maximum in the frontal cortex took place in the first hours of intoxication. The subsequent antidotal therapy resulted in variously high reactivation of cyclosin-inhibited acetylcholinesterase in dependence on the selection of oxime. Practically in all regions under study, a significantly more marked reactivation of the given enzyme in the therapy of intoxication with oxime HI-6 was recorded. For the therapy of acute intoxications with highly toxic cyclosin, oxime HI-6 seems to be a more suitable reactivator of acetylcholinesterase than the hitherto used obidoxime.
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