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  • Title: The effects of beta-carbolines in rats trained with ibogaine as a discriminative stimulus.
    Author: Helsley S, Rabin RA, Winter JC.
    Journal: Eur J Pharmacol; 1998 Mar 19; 345(2):139-43. PubMed ID: 9600629.
    Abstract:
    The structural features and hallucinogenic properties shared by ibogaine and certain beta-carbolines prompted the evaluation of several representative beta-carbolines in rats trained with ibogaine as a discriminative stimulus. In a previous report from our laboratory harmaline completely substituted for ibogaine (83.5%). In the present study, only 6-methoxyharmalan completely substituted (86.3%). However, partial substitution was observed with harmine, harmane, harmalol, and tetrahydro-beta-carboline (THBC). Norharmane and 6,7-dimethoxy-4-ethyl-carboline-3-carboxylate (DMCM) failed to produce appreciable substitution. These results provide evidence for an ibogaine-like ether this extends to the previously reported anti-addictive effects of ibogaine remains to be established.
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