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  • Title: Successful treatment with voriconazole of invasive aspergillosis in chronic granulomatous disease.
    Author: van 't Hek LG, Verweij PE, Weemaes CM, van Dalen R, Yntema JB, Meis JF.
    Journal: Am J Respir Crit Care Med; 1998 May; 157(5 Pt 1):1694-6. PubMed ID: 9603157.
    Abstract:
    A 5-year-old boy with chronic granulomatous disease (CGD) was treated with amphotericin B for an invasive pulmonary Aspergillus nidulans infection. The infection progressed during 6 wk of treatment despite the addition of interferon-gamma (IFN-gamma), filgrastim, and transfusions with donor granulocytes. Treatment with a novel antifungal triazole, voriconazole, resulted in an excellent clinical response.
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