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  • Title: Successful meropenem therapy of a brain abscess and meningitis arising from acute purulent otomastoiditis: case report.
    Author: Paffetti A, D'Aviera L, Le Foche F, Mannozzi P, Mastropietro C, Croce GF, Ferretti G, Rossi F.
    Journal: J Chemother; 1998 Apr; 10(2):132-5. PubMed ID: 9603639.
    Abstract:
    We describe a case of a 25-year-old female with an acute left otomastoiditis, accompanied by a left temporal extradural abscess with moderate perifocal edema and meningitis. Intravenous meropenem (2 g 8-hourly) and intravenous methylprednisolone (40 mg once daily) were commenced empirically. Teicoplanin (400 mg once daily intravenously) was added after 5 days when culture results were available. Teicoplanin was discontinued on day 25 but meropenem and methylprednisolone were continued for a further 15 days, after which the abscess completely resolved without sequelae. No treatment-induced adverse effects or seizures were observed. Thus, in selected patients, antibacterials (in conjunction with a corticosteroid) may be successfully used without surgery to treat brain abscesses and in such circumstances meropenem is a useful option for empiric therapy.
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