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  • Title: Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice.
    Author: Gołab J, Zagozdzon R, Stokłosa T, Kaca A, Dabrowska A, Giermasz A, Feleszko W, Jakóbisiak M.
    Journal: Neoplasma; 1998; 45(1):35-9. PubMed ID: 9605000.
    Abstract:
    Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G-CSF did not influence the proliferative activity of MmB16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB16.
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