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  • Title: An efficacy trial of the malaria vaccine SPf66 in Gambian infants--second year of follow-up.
    Author: Bojang KA, Obaro SK, D'Alessandro U, Bennett S, Langerock P, Targett GA, Greenwood BM.
    Journal: Vaccine; 1998 Jan; 16(1):62-7. PubMed ID: 9607010.
    Abstract:
    In 1994, 630 Gambian infants were immunized with three doses of the synthetic polypeptide malaria vaccine SPf66 or with a control vaccine. No significant protection against first or total attacks of malaria was observed among the children who received SPf66. However, the period of follow-up was short. Thus, 532 children were followed for a second malaria transmission season during which 291 episodes of malaria were detected. Protective efficacies of SPf66 against first attacks of malaria and against all attacks of malaria were 8% [95% CI-20%, 30%] and 2% [95% CI-26% 24%] respectively. SPf66 did not provide any significant degree of protection to Gambian infants during a second year of follow-up.
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