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  • Title: The transition from pubertal development to postmenopause discloses a gonadotropin-releasing hormone-independent mechanism regulating follicle-stimulating hormone release.
    Author: Genazzani AD, Nappi L.
    Journal: Gynecol Endocrinol; 1998 Apr; 12(2):135-44. PubMed ID: 9610427.
    Abstract:
    The reproductive function is tightly dependent on gonadotropin secretion and the optimal activity of the hypothalamus-pituitary axis. This study discusses evidence that supports the possible existence of a GnRH-independent modulator of FSH secretion in humans. Such a hypothesis has been consistently reported in several experimental animals. To test the hypothesis specific times during the physiological development and activity of the hypothalamus-pituitary axis have been evaluated under the use of drugs acting directly on hypothalamic GnRH-secreting neurons, such as GnRH agonists. The possible presence also in humans of such an independent FSH stimulator might be important for the understanding of anovulation and infertility.
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