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  • Title: [Results of cytological and histological studies on the uterine cervix after long-term intake of hormonal contraceptive agents].
    Author: Ebeling K, Ruckhäberle B, Kühndel K, Schulz S, Krönert M.
    Journal: Zentralbl Gynakol; 1976; 98(7):385-92. PubMed ID: 961193.
    Abstract:
    Cytologic examinations with 880 women having constantly used oral contraceptives from one to eight years show no agglomeration of epithelial atypias if the primary status was clearly in the negative. Among 669 histologically sure atypias of cervix uteri the part of women using oral contraceptives for at least one year is significantly lower in carcinoma in situ as well as in early invasive carcinoma. The differences in dysplasia are not significant. The results are also discussed with regard to the efficiency of permanent control examinations before and during the use of oral contraceptions. The demand of a further intensification of cytodiagnostic is derived from these examinations. Studies of the cervical cytological effects of oral contraceptives are reported. Precontraception cytology (all clearly Group 1 or 2) in 880 women was compared with cytological findings after 1-8 year (average 2.4 years) of continuous use of Ovosiston or Non-Ovlon, and with those of a control group of 479 women of similar age. In addition, 669 women with cervical pathology (dysplasia, preinvastive and invasive carcinoma) were questioned on previous use of hormonal contraception for at least 1 year. No evidence could be found that hormonal contraception fostered cytological atypias if initial findings were negative. The proportion of women with cervical pathology who had taken hormonal contraceptives was significantly smaller than their proportion in the ambulatory patient population. These results are discussed in relation to the need for prospective studies of the effects of oral contraceptives.
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