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  • Title: [Does desensitisation of acetylcholine receptors play a physiological role in the neuromuscular synapse?].
    Author: Giniatullin RA, Magazanik LG.
    Journal: Ross Fiziol Zh Im I M Sechenova; 1998; 84(1-2):3-14. PubMed ID: 9612851.
    Abstract:
    After the acetylcholinesterase inhibition, desensitisation of neuro-muscular junctions was found to limit rebundunt activity of postsynaptic membranes and disturb normal transmission. Long-term densensitisation of cholinoreceptors entails shortening of the postsynaptic current decay due, probably, to a high affinity binding the acetylcholine molecules to the desensitised receptors. This may prevent repetitive interactions with active receptors and buffer a certain amount of acetylcholine.
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