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  • Title: [Effect of somatostatin on the chronotropic effect caused by vagal nerve stimulation by a single stimulus].
    Author: Osadchiĭ OE, Pokrovskiĭ VM.
    Journal: Ross Fiziol Zh Im I M Sechenova; 1998; 84(1-2):54-63. PubMed ID: 9612857.
    Abstract:
    In anesthetised cats, vagal stimulation with a single pulse burst evoked a negative chronotropic effect. Somatostatin prolonged the baseline cardiac cycle, diminished inhibitory tonic vagal effect, and increased irs latency. This peptide effect was associated with a narrowing of an area in the cardiac cycle over which even small vagal burst produced a sharp alteration of the sinus node responsiveness to vagal influences.
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