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  • Title: Theanine-induced reduction of brain serotonin concentration in rats.
    Author: Yokogoshi H, Mochizuki M, Saitoh K.
    Journal: Biosci Biotechnol Biochem; 1998 Apr; 62(4):816-7. PubMed ID: 9614715.
    Abstract:
    Following the administration of theanine, the brain tryptophan content significantly increased or tended to increase, but the contents of serotonin and 5-hydroxyindole acetic acid (5HIAA) decreased. The use of inhibitors of serotonin metabolism enable us to speculate that theanine reduced serotonin synthesis and also increased serotonin degradation in the brain.
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