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  • Title: Effect of aging on the activities of acetylcholinesterase, Na+,K(+)-ATPase and Mg(2+)-ATPase in rat pituitary and hypothalamus.
    Author: Tsakiris S, Angelogianni P, Stavridis JC.
    Journal: Z Naturforsch C J Biosci; 1998; 53(3-4):168-72. PubMed ID: 9618933.
    Abstract:
    Acetylcholinesterase (AChE), Na+,K(+)-ATPase and Mg(2+)-ATPase activities were estimated in homogenised rat pituitary and hypothalamus of 4- and 22-month-old rats. AChE activity was not altered in the pituitary of aged compared to adult rats, while it was found decreased by about 40% in the hypothalamus. Na+,K(+)-ATPase activity remained stable in the hypothalamus, while it was decreased by about 38% in the pituitary. Mg(2+)-ATPase activity remained unchanged in the hypothalamus, but was increased by about 83% in the pituitary. This pituitary Na+,K(+)-ATPase inactivation may result in pathological mood and decreased neural excitability and metabolic energy production in aged animals. The age-related alterations of AChE, Na+,K(+)-ATPase and Mg(2+)-ATPase activities may reflect changes in secretion and responses of some hormones of pituitary and hypothalamus.
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