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  • Title: [The effect of nootropic agents on brain mitochondrial function in the dynamics of craniocerebral trauma from the age aspect].
    Author: Novikov VE, Kovaleva LA.
    Journal: Eksp Klin Farmakol; 1998; 61(2):65-8. PubMed ID: 9621180.
    Abstract:
    A craniocerebral trauma was modelled in experiments on one-month-old rats. Oxidative phosphorylation in the brain mitochondria was studied by polarography 1, 4, 7 days and 4 weeks after the trauma. In the posttraumatic period the animals received piracetam (1 g/kg), picamilon (500 mg/kg), pyriditol (100 mg/kg), pantogam (160 mg/kg), ACTH (5-10) (0.1 mg/kg), nooglutyl (25 mg/kg), and GVS (0.5 mg/kg). It was found that piracetam, picamilon, and nooglutyl have a protective effect on the function of the brain mitochondria during the course of a craniocerebral trauma. Nooglutyl surpasses all the other drugs in its influence on the effectiveness of oxidative phosphorylation of mitochondria in immature rats in the posttraumatic period.
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