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  • Title: [Induction of apoptosis through NGF/p75NTR in human glioma cells treated with propentofylline].
    Author: Yamaguchi H, Ukita H, Murakami H, Chiba S, Oshima Y, Ogata A, Ikeda M, Matsumoto A, Satone A, Ide W, Hashimoto I, Kamada H.
    Journal: No To Shinkei; 1998 May; 50(5):407-14. PubMed ID: 9621361.
    Abstract:
    Propentofylline (PPF) is a xanthine derivative and it has been reported that PPF stimulated the synthesis/secretion of nerve growth factor (NGF) by cultured astroglial cells. We have reported that PPF induced apoptosis in human glioma cells and as its mechanism, up-regulation of NGF, Fas, Bax beta and down-regulation of Bcl-2 were assumed. Recent studies demonstrated the presence of apoptosis induced via NGF/p75NTR in developmental neuron, oligodendroglia. In the present study, to examine whether signal cascade via NGF/p75NTR participates the apoptosis in human glioma cells treated with PPF, we investigated the immunohistochemical study using anti-mouse monoclonal antibody, immunoprecipitation and northern blot analysis for p75NTR, NF-kappa B in human glioma cells (U251MG, T98G, U87) treated with PPF. We observed the up-regulation of p75NTR, translocation of NF-kappa B to the nucleus after treatment with PPF in these cell lines. According to above results, it is assumed that apoptosis in human glioma cells treated with PPF was induced via NGF/p75NTR.
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