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  • Title: Possibility of isoproterenol therapy with soft contact lenses: ocular hypotension without systemic effects.
    Author: Bietti G, Virno M, Pecori-giraldi J, Pellegrino N, Motolese E.
    Journal: Ann Ophthalmol; 1976 Jul; 8(7):819-22, 825-9. PubMed ID: 962259.
    Abstract:
    An experimental investigation performed in the rabbit pointed out the possibility of administering isoproterenol at low concentrations with the aid of soft contact lenses presoaked in 0.2% isoproterenol for 60 to 120 minutes. A reduction in intraocular pressure ranging from 23% to 32% was observed in 21 out of 24 glaucomatous patients. Duration of hypotension in 50% of eyes treated was more than 8 hours. Thus, a therapeutic effect was obtained with a concentration (0.2%) approximately 50 times lower than that previously employed clinically (2.4%). No systemic side effects, such as arterial hypotension and increase in heart rate, were noted.
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