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  • Title: The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease.
    Author: Beffert U, Danik M, Krzywkowski P, Ramassamy C, Berrada F, Poirier J.
    Journal: Brain Res Brain Res Rev; 1998 Jul; 27(2):119-42. PubMed ID: 9622609.
    Abstract:
    The importance of apolipoproteins in the central nervous system became increasingly clear with the association in 1993 of the epsilon4 allele of apolipoprotein E with familial and sporadic late-onset Alzheimer's disease. Apolipoprotein E is a ligand for several receptors, most of which are found to some extent in the brain. This review summarizes the various apolipoproteins and lipoprotein receptors found in the brain. A growing body of evidence now implicates irregular lipoprotein metabolism in several neurodegenerative disorders. We then focus on research linking apolipoprotein E and Alzheimer's disease, from clinical studies to biochemical models, which may explain some of the complex neurobiology of this disorder.
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