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  • Title: In vitro activity and clinical evaluation of cefixime in urinary tract infection.
    Author: Asvanich K, Fugpholngam V, Srimuang S, Tanphaichitra D.
    Journal: J Med Assoc Thai; 1998 Apr; 81(4):301-4. PubMed ID: 9623027.
    Abstract:
    Thirty-five women with uncomplicated acute lower urinary tract infections proven by significant pre-treatment bacteriuria (> or = 10(5)CFU/ml) were treated with an oral dose of 100 mg cefixime twice a day for seven days. Thirty five patients included in this study were checked for response to treatment on the last day of therapy, 7-14 days and 4 weeks post therapy. The clinical response and bacterial eradication rate for cefixime were 91.4 per cent (32/35). The infecting organisms, E. coli and Proteus mirabilis, were inhibited at MIC90 = 0.5 and < or = 0.03 microgram/ml, and MBC = 1 and 0.06 microgram/ml respectively. No adverse events were found in this study.
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