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  • Title: [Mycobacterium genavense infection in 2 HIV seropositive patients in Amsterdam].
    Author: Kuijper EJ, de Witte M, Verhagen DW, Kolk AH, van der Meer JT, Dankert J.
    Journal: Ned Tijdschr Geneeskd; 1998 Apr 25; 142(17):970-2. PubMed ID: 9623172.
    Abstract:
    Two patients with an HIV-I infection, a man aged 47 with confusion, aphasia and diarrhoea, and a man aged 32 with dysphagia, a non-productive cough and diarrhoea, were diagnosed as having a disseminated Mycobacterium genavense infection. Both had low counts of CD4+ T lymphocytes. They responded to antimycobacterial treatment. M. genavense was recognized in Geneva in the early nineties as a causative agent of disseminated mycobacterial infections in HIV-seropositive patients with poor cellular immunity. The clinical picture resembles that of a generalized infection with M. avium-intracellulare. M. genavense is a slowly growing mycobacterium which can be isolated and identified using enriched nutrient media and molecular-biological techniques. The infection probably begins in the gastrointestinal tract after oral contamination. DNA of M. genavense can be demonstrated in 25% of the intestinal biopsy samples of non-HIV-seropositive patients.
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