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  • Title: Hepatitis and bone destruction as uncommon manifestations of early syphilis. Report of a case.
    Author: Longstreth P, Hoke AW, Elroy C.
    Journal: Arch Dermatol; 1976 Oct; 112(10):1451-4. PubMed ID: 962344.
    Abstract:
    We describe a patient with a painful lytic lesion of the clavicle and a granuloma of the liver in late secondary syphilis. The classic "moth-eaten" alopecia of the scalp as well as eyebrows and eyelashes suggested syphilis, although an initial false-negative VDRL test for syphilis (prozone phenomenon) caused a delay in diagnosis. Bone as well as liver involvement in early syphilis may be more common than previously recognized.
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