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  • Title: Free-running of plasma melatonin rhythm prior to full manifestation of a non-24 hour sleep-wake syndrome.
    Author: Hashimoto S, Nakamura K, Honma S, Honma K.
    Journal: Psychiatry Clin Neurosci; 1998 Apr; 52(2):264-5. PubMed ID: 9628187.
    Abstract:
    A long-term observation of a sighted man who developed a non-24 h sleep-wake syndrome is reported. A partial entrainment was observed first, whereby the sleep-wake rhythm was entrained by the day-night alternation whereas the circadian rhythm in plasma melatonin was free-running. Two years later, the sleep-wake rhythm of this subject started to free-run together with the melatonin rhythm. Oral administration of melatonin for 2 weeks improved the entrainability of both rhythms but failed to entrain the rhythms completely. It is concluded that the free-running of the circadian pacemaker preceded a full manifestation of a non-24 h sleep-wake syndrome in this particular subject.
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