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  • Title: Stimulation of albumin synthesis by keto analogues of amino acids.
    Author: Kirsch RE, Frith LO, Saunders SJ.
    Journal: Biochim Biophys Acta; 1976 Sep 06; 442(3):437-41. PubMed ID: 963058.
    Abstract:
    (1) The effect of ketoanalogues of branched-chain amino acids on albumin synthesis was examined in two biological systems using the [14C]carbonate technique. (2)alpha-Ketocaproic acid, the ketoanalogue of leucine, was able to reverse the reduced synthesis rate observed when isolated livers, from well-nourished animals were perfused with blood from rats deprived of dietary protein for 48 h. (3) A mixture of ketoanalogues of the three branched-chain amino acids, leucine, isoleucine and valine, was able to increase albumin synthesis per unit dry liver weight to above normal levels when administered intragastrically to rats 16 h after partial hepatectomy.
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