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  • Title: Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats.
    Author: Oitzl MS, Fluttert M, de Kloet ER.
    Journal: Brain Res; 1998 Jun 22; 797(1):159-62. PubMed ID: 9630598.
    Abstract:
    Corticosteroids can facilitate or impair learning and memory processes. We found that the glucocorticoid receptor antagonist RU38486 injected locally into the dorsal hippocampus dose-dependently improved the performance of male Wistar rats in the water maze 24 h after treatment. This observation suggests a discrete specificity of hippocampal glucocorticoid receptors in facilitation of memory.
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