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  • Title: Cerebral hypothermia and circulatory arrest. Review and commentary.
    Author: White RJ.
    Journal: Mayo Clin Proc; 1978 Jul; 53(7):450-8. PubMed ID: 96308.
    Abstract:
    Through the application of low-temperature technology, the critical limits of circulatory arrest to the mammalian brain--the most complex of all body organ systems--can be significantly extended. This presentation reviews three recently developed methods of cooling the brain. The first demonstrates the unique preservation of cerebral tissue as an isolated organ near 0 degrees C with donor perfusion reanimation. The second emphasizes the ability of the intact animal to literally cool its own brain when a simple extracorporeal shunt is utilized. The third outlines a technique of direct hypothermic infusion of the ventricular pathways to achieve deep temperature reductions in brain tissue. Their clinical applications and implications are discussed.
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