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  • Title: The combination of partial liquid ventilation and inhaled nitric oxide in the severe oleic acid lung injury model.
    Author: Uchida T, Nakazawa K, Yokoyama K, Makita K, Amaha K.
    Journal: Chest; 1998 Jun; 113(6):1658-66. PubMed ID: 9631808.
    Abstract:
    STUDY OBJECTIVES: To elucidate the efficacy of the combination of inhaled nitric oxide (NO) and partial liquid ventilation (PLV) in ARDS. DESIGN: Prospective, randomized, controlled study. SETTING: A research laboratory at a university medical center. SUBJECTS: Thirty-two rabbits. INTERVENTIONS: Animals were anesthetized and ventilated via tracheostomy (tidal volume=40 mL; respiratory rate=25 breaths/min; fraction of inspired oxygen=0.99). After 0.08 mL/kg (0.071 g/kg) oleic acid was administered via the central venous route, animals were randomly divided into the following four groups depending on the ventilatory mode: (1) Gas ventilation (GV)-control group: GV was continued throughout the study; (2) GV-NO group: NO inhalation (10 ppm) was performed under GV; (3) PLV-control group: PLV using perflubron (15 mL/kg) was continued until the end of the study; and (4) PLV-NO group: NO inhalation (10 ppm) was performed under PLV. MEASUREMENTS AND RESULTS: NO inhalation improved PaO2 in the PLV-NO group (from 133+/-20 to 167+/-23 mm Hg; p=0.0008), but not in the GV-NO group (from 67+/-6 to 63+/-9 mm Hg), although pulmonary vascular resistance decreased both in the GV-NO (from 4,604+/-328 to 4,337+/-322 dyne x s x cm(-5); p=0.0116) and the PLV-NO group (from 4,727+/-665 to 4,112+/-560 dyne x s x cm(-5); p=0.0036). (Data were expressed as mean+/-SEM.) CONCLUSION: PLV augmented the effect of inhaled NO on pulmonary gas exchange. The combination of PLV and NO inhalation could be effective in severe ARDS.
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