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  • Title: [Design of stimulating agents of non-specific resistance system].
    Author: Masycheva VI, Danilenko ED, Pustoshilova NM, Beliavskaia VA.
    Journal: Vestn Ross Akad Med Nauk; 1998; (4):13-7. PubMed ID: 9633234.
    Abstract:
    The paper briefly reviews a study on the design of drugs enhancing the body's nonspecific resistance to pathogenic agents. To examine the potential regulatory effects on cytokine function was a main trend. The interferon inductor ridostin, dsRNA of microbiological origin, cytokines, as well as the recombinant probiotic strain yielding interferon alpha-2 synthesis were used as a pharmacological agent. This was shown by using a wide range of experimental models wherein these preparations activated the components of the non-specific resistance system resulting in the host's increased capacity to eliminate invasive agents and transformed cells.
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