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  • Title: Mutagenic effects of petrol in Drosophila melanogaster I. Effects of benzene and 1,2-dichloroethane.
    Author: Nylander PO, Olofsson H, Rasmuson B, Svahlin H.
    Journal: Mutat Res; 1978 May; 57(2):163-7. PubMed ID: 96337.
    Abstract:
    Commercial petrol and two of its components, benzene and 1,2-dichloroethane, were tested for mutagenicity in Drosophila melanogaster. The chemicals were given to larvae through their food supply. A genetically unstable sexlinked test system caused by a transposable genetic element was used. Mutagenicity was measured by the frequency of somatic mutations for eye pigmentation. Commercial petrol and 1,2-dichloroethane showed mutagenic activity. With the system used, benzene did not show any mutagenic activity. The high frequency of mutations induced by 1,2-dichloroethane indicate the existence in Drosophila of a metabolic activating system.
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