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  • Title: Hemopericardium and cardiac tamponade after thrombolysis for acute ischemic stroke.
    Author: Kasner SE, Villar-Cordova CE, Tong D, Grotta JC.
    Journal: Neurology; 1998 Jun; 50(6):1857-9. PubMed ID: 9633741.
    Abstract:
    Hemorrhage is the major complication of IV recombinant tissue plasminogen activator (rt-PA) treatment for stroke. We report three patients with mild or indistinct cardiac symptoms prior to thrombolysis in whom hemodynamically significant cardiac tamponade occurred after treatment with rt-PA. Acute ischemic stroke patients may have undetected myocardial or pericardial disease that may pose a risk for hemopericardium and life-threatening tamponade after treatment with rt-PA.
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