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  • Title: Pharmaco-cholangiography with anticholinergic drugs in the dog.
    Author: Burgener FA, Fischer HW, Adams JT, Schabel SI, Plume SK.
    Journal: Br J Radiol; 1976 Sep; 49(585):769-75. PubMed ID: 963385.
    Abstract:
    The effect of atropine and pipenzolate bromide (PB) in different dosage levels was investigated in intravenous cholangiography with 0.6 ml/kg iodipamide infused over 30 minutes in six cholecystectomized dogs (20-36 kg) equipped with Thomas cannulas through which the common bile duct could be cannulated. Doses of 1 mg atropine and 20 mg PB, half the dose given intravenously just prior to the contrast agent and the other half with the iodipamide infusion, had the greatest effect in decreasing the bile flow (atropine-24% at 60, PB-23% at 30 minutes) and increasing the bile iodine concentration (atropine + 16%, PB + 14%). The biliary iodipamide excretion rate was not affected.
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