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  • Title: Novel thiazolidinedione derivatives with retinoid synergistic activity.
    Author: Ebisawa M, Kawachi E, Fukasawa H, Hashimoto Y, Itai A, Shudo K, Kagechika H.
    Journal: Biol Pharm Bull; 1998 May; 21(5):547-9. PubMed ID: 9635519.
    Abstract:
    Several arylmethylidene thiazolidinediones were synthesized and their retinoidal activities were examined. TZ181 (7a), having a benzanilide skeleton, exhibited differentiation-inducing activity in HL-60 cell assay, while TZ191 (7b), the N-methylated analog of TZ181 (7a), TZ245 (9) and TZ335 (10) acted as retinoid synergists like the RXR-selective ligand, LGD1069 (5).
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