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  • Title: Prognostic value of gastric intramucosal pH in critically ill children.
    Author: Casado-Flores J, Mora E, Pérez-Corral F, Martínez-Azagra A, García-Teresa MA, Ruiz-López MJ.
    Journal: Crit Care Med; 1998 Jun; 26(6):1123-7. PubMed ID: 9635665.
    Abstract:
    OBJECTIVE: To determine the association of tonometrically measured gastric intramucosal pH (pHi) to the occurrence of multiple organ dysfunction syndrome (MODS) and death in critically ill children. DESIGN: Prospective, observational study. SETTING: Pediatric intensive care unit (ICU) of a teaching children's hospital. PATIENTS: Fifty-one critically ill children admitted (median age 5.4+/-5 [SD] yrs; range 1 mo to 16 yrs) with the following diagnoses: post major surgery (n=26), sepsis (n=8), multiple trauma (n=5), acute respiratory distress syndrome (n=4), and "miscellaneous" (n=8). INTERVENTIONS: Placement of a tonometric catheter. MEASUREMENTS AND MAIN RESULTS: Pediatric Risk of Mortality (PRISM) score and clinical data were collected on admission and pHi daily during their stay in the pediatric ICU. A sigmoid tonometer was used to determine the pHi. Unconditional logistic regression was used to investigate the prognostic value of pHi. On admission, 26 patients presented with low gastric pHi (< or =7.35) and 17 of them had values of <7.30. The mortality rate in children with pHi <7.30 was 47.1% (95% confidence interval, 26.2 to 69) in contrast with an 11.7% mortality rate (95% confidence interval, 4.6 to 26.6) in children having a pHi of > or =7.30 (p=.015). The pHi and PRISM score on admission were independent predictive factors of death. The risk of mortality is increased when the pHi is low (odds ratio=2.5). However, we did not find the pHi to be a predictor for developing MODS. CONCLUSIONS: Our results show that pHi is an independent predictor of mortality in patients admitted to a pediatric ICU. Although no relationship was observed between the risk of MODS and gastric pHi, the univariate difference of 21% vs. 41% is highly suggestive. The pHi determination is a minimally invasive procedure and well tolerated in children of all ages.
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