These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tissue-specific involvement of multiple mitochondrial DNA deletions in familial mitochondrial myopathy.
    Author: Nishizuka S, Tamura G, Goto Y, Murayama K, Konno T, Hakozaki M, Nonaka I, Tohgi H, Satodate R.
    Journal: Biochem Biophys Res Commun; 1998 Jun 09; 247(1):24-7. PubMed ID: 9636647.
    Abstract:
    It is still uncertain how deleted mitochondrial DNA (mtDNA) is distributed to each tissue during development, although deletions of mtDNA have been extensively observed in various pathologic conditions. This paper presents two Japanese siblings with progressive external ophthalmoplegia exhibiting multiple mtDNA deletions. In one patient, similar multiple mtDNA deletions were found in skeletal muscle specimens as well as in the spinal cord but not in the myocardium, liver or leukocytes. A similar deletion pattern was found in the skeletal muscle but not in the leukocytes of the other patient. The results suggest the complex mechanism to generate, expand and eliminate the deleted mtDNA in humans.
    [Abstract] [Full Text] [Related] [New Search]