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  • Title: Role of iron in the natural history and clinical course of hepatitis C disease.
    Author: Shedlofsky SI.
    Journal: Hepatogastroenterology; 1998; 45(20):349-55. PubMed ID: 9638405.
    Abstract:
    The following review evaluates the current data implicating a role for hepatic iron in enhancing the liver injury in patients with chronic hepatitis C infection. Iron removal lowers transaminases, but doesn't appear to improve responsiveness to interferon-alpha therapy. An important effect of iron removal might be to delay progression of liver injury to fibrosis and cirrhosis. Until such a hypothesis is disproven, phlebotomy therapy for even mildly iron-loaded HCV patients is recommended.
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