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  • Title: Separate histogenesis of combined hepatocellular and cholangiocellular carcinoma in two patients.
    Author: Nagafuchi Y, Okamoto K, Shono M, Higure A, Todoroki H, Itoh H, Takeda S, Katumoto F, Toyoshima S.
    Journal: Hepatogastroenterology; 1998; 45(20):523-7. PubMed ID: 9638442.
    Abstract:
    Double primary liver carcinomas, i.e. hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC) are rare. Two patients in whom double primary liver carcinomas were surgically resected are described herein. Case 1: A 51-year-old Japanese man with chronic type B hepatitis underwent hepatectomy for primary HCC with intrahepatic metastasis. Case 2: A 67-year-old Japanese man with a history of rectal cancer and CCC underwent lateral hepatic segmentectomy for a suspected recurrence of intrahepatic CCC. Lack of direct contact between tumors, no evidence of histological transition and clearly different immunohistochemical staining for cytokeratin support a distinct histogenesis of the tumors in these two patients. The findings indicate that combined HCC and CCC can arise synchronously or metachronously as an intrahepatic double cancer.
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