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  • Title: [The study of the influence of aminoglycoside antibiotics on the hearing organs in children].
    Author: Gryczyńska D, Andrzejewski J, Wlazłowski J, Zgoła J.
    Journal: Otolaryngol Pol; 1997; 51(6):511-6. PubMed ID: 9640045.
    Abstract:
    The paper presents results of audiologic assessments hearing examinations in 19 children that received aminoglycosides in cases of pneumonias, meningitis and sepsis. Examination of hearing acuity with otoscopic assessment of the ears, tympanometry, ABR and acoustic otoemission were performed before, directly after infusion and after completion of treatment. After a laryngological examination and of the hearing acuity, tympanometry and the ABR the authors have concluded the normal state of the hearing organ. Only in the examination of the acoustic otoemission produced during the treatment it was found the amplitude was flattened or there was no otoeimssion for some individual frequencies in relation to records taken before the treatment. The authors emphasize that among risk factors of ototoxic effect of some medicines are of importance the following: patient's age, uncontrolled increase in blood drug concentration, increase in daily dosage, cumulation of the drug in the organism, prolonged treatment with the drug.
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