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  • Title: Cytotoxic quassinoids from Simaba cedron.
    Author: Ozeki A, Hitotsuyanagi Y, Hashimoto E, Itokawa H, Takeya K, de Mello Alves S.
    Journal: J Nat Prod; 1998 Jun 26; 61(6):776-80. PubMed ID: 9644063.
    Abstract:
    Four new quassinoids, cedronolactones A-D (1-4), together with nine known compounds, simalikalactone D (5), chaparrinone (6), chaparrin (7), glaucarubolone (8), glaucarubol (9), samaderine Z (10), guanepolide (11), ailanquassin A (12), and polyandrol (13), were isolated from the wood of Simaba cedron. The chemical structures of 1-4 were elucidated on the basis of their chemical and spectral properties. Cedronolactone A (1) was shown to exhibit a significant in vitro cytotoxicity (IC50 0.0074 microg/mL) against P-388 cells.
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