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  • Title: [The effect of serotonin antibodies on the behavior of C57Bl/6 mice in an open field and on the level of monoamines in the brain structures].
    Author: Trekova NA, Khlopushina TG, Basharova LA, Vetrilé LA, Mikovskaia OI, Evseev VA.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1998; 48(2):251-9. PubMed ID: 9644805.
    Abstract:
    Mice of C57BL/6 strain were singly injected intraperitoneally with antibodies (AB) to serotonin (5-HT). The "open-field" testing in different periods after the AB injection revealed a depression of behavior within 1.5 h which changed for activation within 1 day and, again, depression within 5 days after the injection. The analysis of neurotransmitter content in the sensorimotor cortex and hypothalamus revealed increased levels of serotonin and, especially, dopamine in the cortex within 1 day. The cortex serotonin level within 5 days was also increased. The possible mechanisms are discussed of neurotropic action of AB to 5-HT.
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