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  • Title: [Antibodies against prolactin in patients with systemic lupus erythematosus and hyperprolactinemia].
    Author: Leaños Miranda L, Bustos López HH, Fraga Mouret A, Blanco Favela F, Dalila Pascoe Lira ME, Dalila Pascoe Lira C.
    Journal: Ginecol Obstet Mex; 1998 May; 66():179-86. PubMed ID: 9646575.
    Abstract:
    We investigated patients with lupus erythematosus to detect the presence of hyperprolactinemia and to determine it's origin. From the seric specimens obtained in 225 patients with LES, we found 37 (14.5%) with hyperprolactinemia and they were trated with polyethylenglicol, in 11 of 37 patients (29.7%) had a high significance of prolactin precipitation (PRL). The test in gel filtration shown the big-big PRL (Molecular weight > 100 kDa) was the predominant form from PRL seric in these patients and no woman had clinic effects of hyperprolactinemia as galactorrhea and/or amenorrhea. The big-big PRL essence was due to an antibody, with it was found like a immune complex (Ig-PRL). This evidence suggest the patients with LES and hyperprolactinemia have a very high incidence of macroprolactinemia relationated to antibodies anti-PRL, and in spite of the hyperprolactinemia not have clinical effects like amenorrhea and/or galactorrhea, and it is other cause to explain the high incidence of hyperprolactinemia in patients with LES.
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