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  • Title: Fucosyltransferase-catalyzed formation of L-galactosylated Lewis structures.
    Author: Stangier K, Palcic MM, Bundle DR, Hindsgaul O, Thiem J.
    Journal: Carbohydr Res; 1997 Dec; 305(3-4):511-5. PubMed ID: 9648268.
    Abstract:
    The Lewis (alpha 1-3/4) fucosyltransferase isolated from human milk could be used for preparative fucosylations of the disaccharide acceptors Gal(beta 1-3)GlcNAc(beta 1-O)R (at position OH-4) and Gal(beta 1-4)GlcNAc(beta 1-O)R (at position OH-3) [R = (CH2)8COOMe]. As donors GDP-L-Gal and deoxygenated derivatives were used to lead to a series of novel modified trisaccharides of the Lewis(a) and the Lewis(x) type, respectively.
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