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  • Title: Drug eruption due to Bufferin showing erythema exsudativum multiforme with a photo-recall-like phenomenon.
    Author: Lee SG, Matsuyoshi N, Ohta K, Horiguchi Y, Imamura S.
    Journal: Eur J Dermatol; 1998 Jun; 8(4):280-2. PubMed ID: 9649658.
    Abstract:
    A 21-year-old woman who had been taking several kinds of analgesics to treat dysmenorrhea developed episodic attacks of a purpuric macular eruption and a burning sensation on unexposed areas of the upper chest and back where she had sustained severe sunburn eight months earlier. Target-like lesions developed on these areas after intake of Bufferin, a combination of aspirin and dialuminate. After the eruptions had abated following systemic administration of a corticosteroid agent, a challenge test was performed, using a quarter of a tablet of Bufferin. The patient developed a temporary burning sensation and a erythematous color on the previously sunburned skin. We diagnosed this case as a drug eruption due to Bufferin showing erythema exsudativium multiforme with a photo-recall-like phenomenon. In our case, skin tests would be useful to confirm the causal drug.
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