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  • Title: On the intrinsic mechanisms of spontaneous motility in chick embryos.
    Author: Sedlácek J.
    Journal: Cesk Fysiol; 1998 Jun; 47(2):53-6. PubMed ID: 9650421.
    Abstract:
    Our experimental study was aimed on the problems of co-operation of NMDA- and NO-ergic mechanisms in the genesis of spontaneous motility in 17-day-old chick embryos. 1. Blockade of NO-synthase (NOS) by 7-nitro indazole prevented effect of an activation cocktail (NMDA + L-arginine). 2. Simultaneous blockade of NOS and of polyamine site in NMDA-receptor by arcaine was revealed by increased NMDA-activation of the spontaneous motility and by blockade of L-arginine and cocktail effects. 3. The blockade of NMDA-activation, depression of L-arginine activation and short-lasting potentiation of cocktail effect. 4. Blockade of NMDA mechanism by Mg2+ abolished activatory effect of both NMDA and L-arginine. The initial activation remained from the cocktail effect only. Results were considered as an evidence of a possible co-operation among NMDA- and NO-ergic mechanisms in the development of the embryonic spontaneous motility.
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